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June 1952

LESIONS OF THE CENTRAL NERVOUS SYSTEM IN DISSEMINATED LUPUS ERYTHEMATOSUS

Author Affiliations

NEW YORK

From the Department of Neurology, Columbia University College of Physicians and Surgeons, and the Neurological Institute, Presbyterian Hospital.

AMA Arch NeurPsych. 1952;67(6):745-753. doi:10.1001/archneurpsyc.1952.02320180022003
Abstract

THERE have been numerous reports of the manifestations of acute disseminated lupus erythematosus in the various organs of the body since Kaposi1 first formulated the concept of the grave form with systemic disturbances. Neurologic signs and symptoms have been reported to occur in the course of the disease, but it has been indicated that the involvement of the central nervous system is not well understood and that the morbid anatomy of the nervous system in this illness requires much further investigation.2

Since 1930, autopsy has been performed in 18 cases of acute lupus erythematosus at the Presbyterian Hospital. The central nervous system was examined in six cases, and in three of these widespread lesions were found. It is the purpose of the present paper to report these cases in detail and to review the pertinent literature.

REPORT OF CASES 

Case 1.—  L. C., an unmarried white woman aged

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