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November 1952

PROTEIN CONTENT OF SPINAL FLUID IN DIABETES MELLITUSReport on One Hundred Cases

Author Affiliations

NEW YORK

From the Neuropsychiatric Service of the Morrisania City Hospital, and the Department of Neurology of the New York Medical College, Flower and Fifth Avenue Hospitals.

AMA Arch NeurPsych. 1952;68(5):641-644. doi:10.1001/archneurpsyc.1952.02320230067007
Abstract

ELEVATION of the total-protein content of the cerebrospinal fluid has been noted in several disorders of metabolism and in diseases in which the metabolism is disturbed. Thus, the protein value of the spinal fluid has been found increased in myxedema (Thompson and associates1), chronic nephritis (Lyttle and Rosenberg2), uremia (Madonick, Berke, and Schiffer3), and Cushing's syndrome (Trethowan and Cobb4). Although an increase in the protein content of the spinal fluid of diabetic patients with peripheral neuropathy has been reported fairly frequently (Root and Rogers,5 Jordan,6 Rundles,7 Epstein8), information regarding the protein concentration of the spinal fluid in diabetic patients without clinical neurologic involvement is meager. Mestrezat9 and Levinson10 stated that the spinal-fluid protein value is normal. Lochelongue11 found increased protein in the spinal fluid in diabetes mellitus. Eskuchen12 indicated that there may be a slight increase in globulin

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