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April 1953

PSYCHOTIC REACTIONS IN PROBLEM DRINKERS TREATED W!TH DISULFIRAM (ANTABUSE®)

Author Affiliations

SAN FRANCISCO

From the Langley Porter Clinic, California State Department of Mental Hygiene, and the Division of Psychiatry of the University of California School of Medicine.

AMA Arch NeurPsych. 1953;69(4):415-426. doi:10.1001/archneurpsyc.1953.02320280003001
Abstract

A PROGRAM for the treatment of problem drinkers with disulfiram (antabuse®)1 was instituted at the clinic in April, 1949. The purpose of the study has been to investigate the psychologic, pharmacologic, and therapeutic effects of this treatment and to determine whether disulfiram is a safe drug to use in the treatment of alcoholism.

MATERIAL AND METHOD  Selection of patients for preliminary study was limited to those with a chief complaint of alcoholism. Approximately one-half the patients came of their own volition; 10 were transfers from a state hospital and under commitment for alcoholism, and the remainder were referred by spouse, physician, employer, or other person. One out of five patients asking for treatment by telephone failed to keep a first appointment. Approximately one patient out of seven who kept the appointment decided that he did not want this type of treatment after hearing that it was not a "quick

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