THE RECENT advances in the measurement and understanding of endocrine and nervous mechanisms have given impetus to the search for organic physiological causes or correlates in the psychoses. Pincus, Hoagland, and their colleagues1 have presented evidence from their impressive studies that dysfunction of the adrenal cortex may play an important role in the genesis or development of schizophrenia. The complex mechanisms involved in the regulation and maintenance of body temperature have been found by Buck, Carscallen, and Hobbs2 to be disorganized in early schizophrenia.
Pincus and associates1 reported that in schizophrenia there is an absence or a decrease in the adrenocortical response to stimulation. As those schizophrenics who did not show an adequate adrenocortical response to stress did not show one to corticotropin (ACTH) either, they deduced that the defect lay in the adrenal cortex itself. They later presented evidence3 that in schizophrenia a poor response
STEVENSON JAF, METCALFE EV, HOBBS GE. EOSINOPHILE RESPONSE IN SCHIZOPHRENIC PATIENTSInfluence of the Diurnal Cycle and the Type of Schizophrenia. AMA Arch NeurPsych. 1953;70(6):802-812. doi:10.1001/archneurpsyc.1953.02320360117009