THE STUDY to be described was carried out to determine the effect of cortisone in a case of idiopathic epilepsy. McQuarrie and associates1 had previously demonstrated that desoxycorticosterone reduced the number and severity of seizures provoked by a vasopressin hydration regimen. Aird and Gordon2 also showed that desoxycorticosterone reduces the severity and frequency of seizures in epileptics on no other treatment and referred to the drug as an anticonvulsant. Both Aird and Gordon2 and Klein and Livingstone3 also found that desoxycorticosterone reduced electroencephalographic abnormalities in epileptics. Because of the similarity of desoxycorticosterone and cortisone in structure and in certain metabolic actions, it was thought that cortisone might be similarly anticonvulsant.
The decision first had to be made whether to conduct limited observations on a group of epileptics or whether to study one patient intensively. The latter plan was followed. The patient chosen had severe epilepsy, was
HATFIELD CB, WILSON DR, RICE HV. METABOLIC AND ELECTROENCEPHALOGRAPHIC CHANGES IN IDIOPATHIC EPILEPSYA Detailed Case Study. AMA Arch NeurPsych. 1954;71(2):208-216. doi:10.1001/archneurpsyc.1954.02320380074009