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March 1954

EFFECT OF INTRACAROTID IODOPYRACET (DIODRAST) UPON CEREBRAL BLOOD FLOW

Author Affiliations

DURHAM, N. C.

From the Division of Neurological Surgery, Department of Surgery, and Department of Pathology, Duke University School of Medicine and Duke Hospital.

AMA Arch NeurPsych. 1954;71(3):358-361. doi:10.1001/archneurpsyc.1954.02320390088008
Abstract

PREVIOUS anatomical studies have revealed that it is possible to produce severe cerebrovascular injury following the intracarotid injection of iodopyracet (Diodrast).* This injury is characterized by striking vasodilatation and progressive changes in vascular permeability, as well as evidence of stasis of blood flow with accompanying edema and hemorrhage. Because of the discrepancy in these observations and the prevailing view that arteriographic accidents are vasospastic in nature, it was thought worth while to attempt a corroboration of these anatomical findings by means of physiological experiment.

METHODS  The experimental animals were healthy, young adult rabbits and Macacus rhesus monkeys. During the period of surgical preparation, light intravenous pentobarbital (Nembutal) anesthesia was used for all rabbits and one monkey. In the remaining monkeys light ether-oxygen mixtures were used. The right common carotid artery was exposed and cannulated. The external carotid artery was ligated in the rabbit preparations. A femoral artery and vein were

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