[Skip to Content]
[Skip to Content Landing]
Other
August 1954

SERUM LIPID STUDIES IN MULTIPLE SCLEROSIS

Author Affiliations

WASHINGTON, D.C.

From the Departments of Biological Chemistry and Neurology, Georgetown University School of Medicine.

AMA Arch NeurPsych. 1954;72(2):154-159. doi:10.1001/archneurpsyc.1954.02330020022002
Abstract

LIPID STUDIES in multiple sclerosis should have a special significance because J the disease process involves a breakdown of the lipid-rich myelin. Studies on the serum lipids in this disease have been reported recently. Jones and associates1 found an elevation of cholesterol; Wilmot and Swank,2 however, examined the total lipid and cholesterol content and concluded that there were no significant changes. Chiavacci and Sperry3 likewise were unable to find an increase in serum cholesterol, although 11 out of 52 patients did give increased values. Dobin and Switzer4 found that the free and esterified cholesterol levels are elevated in multiple sclerosis. Schild and associates5 and Geinitz and associates6 stated that there was probably an increase in lipoproteins, since the thymol turbidity test, which is frequently positive in multiple sclerosis, depends mainly on the lipids bound to beta globulin. Aird and co-workers7 carried out ultracentrifuge

×