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December 1954

USE OF N-METHYL-a,a-METHYLPHENYLSUCCINIMIDE IN TREATMENT OF PETIT MAL EPILEPSY

Author Affiliations

NEW YORK

From Columbia University College of Physicians and Surgeons, and the Division of Child Neurology, Neurological Institute.

AMA Arch NeurPsych. 1954;72(6):720-725. doi:10.1001/archneurpsyc.1954.02330060056008
Abstract

FOR SEVERAL years we have been searching for new and more efficient petit mal drugs to supplement the dearth of standard drugs already available to the medical public. We have tested a number of different chemical groups, but to date that group of chemical compounds known as the succinimides appears to offer the most promise. It has been our opinion, too, developing out of our clinical experience, that it is futile to hope to find one drug which will be the touchstone of effectiveness in all cases of petit mal epilepsy. The armamentarium of petit mal medication is badly in need of drugs other than phenobarbital or trimethadione (Tridione), regardless of how effective these drugs may be, since it is common knowledge that whereas one drug may not be beneficial in a particular case, another may be highly effective.

While petit mal seizures are not so dramatic as those of

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