The introduction of chlorpromazine and reserpine into the therapeutic armamentarium of the practicing physician has posed the problem of which drug to use in which type of nervous or mental disorder. The evaluation of the effectiveness of any treatment in psychiatric cases has always been difficult. This is made even more difficult when one is dealing with two drugs which are so similar in action and yet so consistent in their effect from one case to another.
It has been my experience that the same patient may not be able to tolerate one drug and yet respond nicely to the other. Much time is lost in trying to find out which drug is the more effective. As a consequence, an increasing number of patients are being started on combined chlorpromazine-reserpine therapy initially, with satisfactory results. The following study is an attempt to compare the results of chlorpromazine alone with reserpine
LEMERE F. Combined Chlorpromazine-Reserpine Therapy of Psychiatric Disorders. AMA Arch NeurPsych. 1955;74(1):1–2. doi:10.1001/archneurpsyc.1955.02330130003001