Since mephenesin was introduced as a muscle relaxant by Berger and Bradley,1 in 1946, there have been many clinical reports concerning its use in spastic and hyperkinetic states.* No uniformity was noted in regard to its efficacy in the treatment of these disorders. More recently, the use of mephenesin was extended to the treatment of anxiety states.† Once again, ensuing clinical reports concerning its efficiency in alleviating anxiety were of varying degrees of enthusiasm.‡ The increase of muscle tension in anxiety states is well known. To our knowledge, there have been no quantitative studies of muscle tension responses after the administration of mephenesin in humans. We therefore felt it would be useful to study quantitatively muscle tension in anxious people and to report whether or not mephenesin could be shown to reduce muscle tension, in a predictable fashion.
Anxiety is a subjective state associated with physiologic changes, which may
DICKES R, FLAMM GH, COLTRERA J, TOBIN M. The Effect of Mephenesin on Muscle TensionAn Experimental Study. AMA Arch NeurPsych. 1955;74(6):590-597. doi:10.1001/archneurpsyc.1955.02330180008002