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October 1956

Cerebrospinal fluid Thrombocyte-Agglutinating Substance in Multiple Sclerosis

Author Affiliations


From Nørre Hospital (Chief: Prof. E. Jarløv, M.D.), and the Neurological Department of the Municipal Hospital (Chief: Dr. K. Krabbe, M.D.).

AMA Arch NeurPsych. 1956;76(4):343-354. doi:10.1001/archneurpsyc.1956.02330280001001

Introduction  The purpose of this work is to find out whether in multiple sclerosis it can be demonstrated that there are changes in the cerebrospinal fluid which may explain why plaques seem to occur at definite sites of predilection, that is, around the small veins in the central nervous system and periventricularly.Cruveilhier1 was the first to compare the areas of sclerosis with the results of embolism. Later, Rindfleisch2 stressed the connection between plaques and blood vessels; however, he was not of the opinion that the plaques were formed as a result of circulatory disturbances alone. Charcot3 described vascular obstruction. Ribbert4 considered he had demonstrated that blockage of the arteries in the central nervous system by white cells occurs, although his investigations do not confirm this claim. Williamson5 emphasized the significance of venous thrombi but gave no further details. Borst6 formulated a special vascular