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March 1957

Effects of Centrally Acting Drugs on Two Tests of Brain Damage

Author Affiliations

Bethesda, Md.

AMA Arch NeurPsych. 1957;77(3):328-332. doi:10.1001/archneurpsyc.1957.02330330114018
Abstract

The purpose of the present investigation was to measure the effects of several centrally acting drugs on the performance of tasks designed primarily for studying the effects of brain damage. The tasks employed were the Continuous Performance Test1 and the Wisconsin Card Sorting Test.2 The Continuous Performance Test (C. P. T.), designed to measure sustained attention, is essentially a visual discrimination task, in which the subject must respond within short periods of time to briefly presented stimuli. In general, brain-damaged subjects perform more poorly on it than do non-brain-damaged controls. The Wisconsin Card Sorting Test was designed by Grant and Berg to provide quantitative measures of the kind of rigid and concrete performance that brain-damaged persons display on the Weigl-Goldstein-Scheerer3 Color Form Sorting Test. A comparison on these tests of the effects of brain damage and the effects of centrally acting drugs, especially when the locus of

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