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June 1957

Relation of Physiological and Psychological Effects of Lysergic Acid Diethylamide

Author Affiliations

Bethesda, Md.

AMA Arch NeurPsych. 1957;77(6):657-658. doi:10.1001/archneurpsyc.1957.02330360115013

The purpose of this report is to show the relationship that exists between a number of physiological measures and concomitant psychological effects of lysergic acid diethylamide (LSD).

LSD and other centrally acting drugs will produce a variety of physiological and psychological changes in man; however, there has been no attempt to determine whether the persons who show the greater physiological changes also show the greater psychological changes. It is usually assumed that when two subjects receive a drug the subject who shows the greater physiological change will also report that he is more affected by the drug, and that if his behavior were measured he would also show the greater impairment in this behavior. In the present study data will be presented to show that this is only partially true.

Methods  Ten normal volunteers between the ages of 18 and 23, six male and four female, served as subjects. All