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July 1957

Drug and Milieu Effects with Chronic Schizophrenics

Author Affiliations


From the Eastern Pennsylvania Psychiatric Institute and the Philadelphia State Hospital.

AMA Arch NeurPsych. 1957;78(1):89-94. doi:10.1001/archneurpsyc.1957.02330370103015

Introduction  It has long been known in therapeutics that the prescription of several medicinal substances is often more effective than giving one alone. Many substances are known to act as adjuvants or as potentiators of active agents, or they may tend to counteract undesirable side-effects. There immediately comes to mind the use of acetophenetidin (Phenacetin) and caffeine along with acetylsalicylic acid (aspirin), and dextroamphetamine sulfate U. S. P. with amobarbital, as well as any number of newer proprietary preparations which combine the effects of two or more drugs.When the action of a drug on a given type of patient is well known, it may be meaningfully combined with an equally well-known agent, and the contribution of each may be clinically differentiable. Relatively unknown agents may also be given in combination, in the hope that their combined effectiveness will be greater than that of either drug given singly. In this