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March 1958

Pupil Dilatation in Normal and Schizophrenic Subjects Following Lysergic Acid Diethylamide Ingestion

Author Affiliations

Worcester, Mass.

From the Dementia Praecox Research Service of the Worcester State Hospital.

AMA Arch NeurPsych. 1958;79(3):341-344. doi:10.1001/archneurpsyc.1958.02340030105017
Abstract

In view of findings that schizophrenic patients require higher doses of lysergic acid diethylamide to produce psychologic disturbances than do normal subjects,1-7 this study was made to determine whether the absorption of LSD-25 into the central nervous system of such patients, as measured by pupillary dilatation, differed from that of normal subjects.

The recent study of the metabolism of LSD-25 by Axelrod, Brody, Witkop, and Evarts8 demonstrated the presence of considerable amounts of the drug in the brain and cerebrospinal fluid of a cat after intravenous injection of 1.0 mg/kg., indicating that the substance could pass the blood-brain barrier. This was true also in the monkey injected intravenously in a dose of 0.2 mg/kg., where the biologic half-life (the time required for the plasma level to fall to half its value) was found to be about 100 minutes.

A constantly noted phenomenon after the ingestion of LSD-25 is

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