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This lavishly illustrated monograph is based upon a minute study of 20 autopsies on multiple sclerosis, with copious references to the literature. The author emphasizes the histopathologic findings in his cases in relation to experimental neuroallergy. He finds thromboses and hemorrhages in a minority of cases and considers them secondary or symptomatic. On the other hand, the perivascular infiltrations occurring both at the periphery of lesions and at a distance are commoner, and are believed to be primary and not merely symptomatic. The material does not permit positive opinion as to whether the demyelination or the inflammation comes first, but the infiltrations, as well as the formation of microgranulomas, appear to be an integral part of the process.
The disease process is a continuing one, as can be shown by the presence of acute and subacute lesions at the periphery of some of the sclerotic patches, even though the beginning
Freeman W. Die neuroallergischen Beziehungen in der Histopathologie der multiplen Sklerose. AMA Arch NeurPsych. 1958;80(2):197. doi:10.1001/archneurpsyc.1958.02340080067017