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November 1958

Cortical and Subcortical Electrical Effects of Psychopharmacologic and Tremor-Producing Compounds

Author Affiliations

Iowa City

From the Departments of Neurology, Anatomy, and Psychiatry, State University of Iowa College of Medicine.

AMA Arch NeurPsych. 1958;80(5):544-553. doi:10.1001/archneurpsyc.1958.02340110014002
Abstract

Introduction  The psychopharmacologic effects of chlorpromazine and reserpine have been frequently described. In addition, reversible Parkinsonian syndromes, particularly the development of alternating, rest-type tremors have been reported as side-effects in humans (Kinross-Wright1; Dundee2; Richman and Tyhurst3; Ayd4; Bader5; May and Voegele6), monkeys (Windle et al.7), and cats (Kaelber and Joynt8).Tremorine (1,4-dipyrrolidino-2-butyne), an experimental drug, synthetized by Abbott Laboratories, has been shown to produce the major components of the Parkinsonian syndrome in a number of laboratory animals (Everett, Blockus, and Shepperd9). Whereas chlorpromazine will produce tremors of the rest type in about 40% of cats, Tremorine in our experience has a 100% effect. Although the aforementioned drugs produce marked and diffuse parasympathetic responses in animals, it is to be noted that chlorpromazine and reserpine result in a reduction of spontaneous motor activity, whereas Tremorine produces an increase. Pentobarbital (Nembutal), which under

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