Author Affiliations: Department of Anatomy (Dr Taranikanti) and Department of Biochemistry (Dr Banerjee) (email@example.com), College of Medicine and Health Sciences, Muscat, Oman.
To the Editor: The meta-analysis by Ms Thompson and colleagues showed that antihypertensive treatment of patients with a history of cardiovascular disease (CVD) but without hypertension reduces cardiovascular morbidity and mortality.1 Two key issues need to be examined.
The authors should provide the number needed to treat (NNT) to help determine the effectiveness of antihypertensive treatment for the different outcomes. Even if the NNT was high, the long-term use of antihypertensive drugs in prehypertensive patients with a history of CVD might be justified, taking into consideration the critical clinical consequences.
Taranikanti V, Banerjee Y. Antihypertensive Treatment of Patients With Cardiovascular Disease but Without Hypertension. JAMA. 2011;305(21):2170-2171. doi:10.1001/jama.2011.704