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Book and Media Reviews
June 8, 2011

Adult Acute Lymphocytic Leukemia: Biology and Treatment

Author Affiliations

Author Affiliations: Hematology/Oncology, University of Arkansas for Medical Sciences; and Central Arkansas Veterans Healthcare System, Little Rock (mehtapaulette@uams.edu).

JAMA. 2011;305(22):2353-2358. doi:10.1001/jama.2011.795

Acute lymphocytic leukemia is the most common hematologic malignancy in children. In young children it is also largely curable, with more than 90% of afflicted children achieving long-term remission. This phenomenal success was the first major triumph against cancer of any type.

In contrast, acute lymphocytic leukemia in adults is uncommon and remains largely incurable, despite much effort made in clinical trials and empirical research. The focus of this book is on acute lymphocytic leukemia in adults, with frequent allusions to the childhood form of disease. Despite the subtitle, the book includes diagnosis, complications, survivorship, palliation, and new developments in research in new targets, chemotherapy and molecular drugs, and immune therapies.

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