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June 8, 2011

Antibiotic Resistance and the Future

Author Affiliations

Author Affiliations: Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal (

JAMA. 2011;305(22):2293-2294. doi:10.1001/jama.2011.761

To the Editor: Dr Hughes1 pointed out the burden of antibiotic resistance and the challenges that it poses for the future. Southeast Asia in particular has served as the birthplace of many drug-resistant organisms.2,3 Drug-resistant forms of Neisseria gonorrhoeae, malaria, mycobacterium tuberculosis, cholera, kala-azar, Klebsiella, Pseudomonas, and Acinetobacter are prevalent in this region.4 Newer resistant forms have emerged, such as New Delhi metallo-β-lactamase 1, that have no effective treatment and have shown the capability of spreading globally.5

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