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January 27, 1999

Animal Experimentation

Author Affiliations

Margaret A.Winker, MDIndividualAuthorPhil B.FontanarosaMD, Senior EditorsIndividualAuthor

JAMA. 1999;281(4):325. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-4-jbk0127

To the Editor: The observation by Dr Kahn and colleagues1 is important and merits further research. In 1970, we extended earlier work2 establishing that the probability of metastases from colon cancers to lymph nodes was independent of the size of the colon cancer. When we compared metastasizing and nonmetastasizing variants, the most statistically significant characteristic of patients with metastasizing variants was past or present nonmelanoma skin cancer. The host's exposure to factors (ie, UV rays) severe enough to cause skin cancers appears to have a systemic effect not fully studied.

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