Margaret A.Winker, MDIndividualAuthorPhil B.FontanarosaMD, Senior EditorsIndividualAuthor
Copyright 1999 American Medical Association.
All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999
To the Editor: The observation by Dr Kahn and
colleagues1 is important and merits further research. In
1970, we extended earlier work2 establishing that the probability of metastases from colon cancers to lymph nodes was
independent of the size of the colon cancer. When we compared
metastasizing and nonmetastasizing variants, the most statistically
significant characteristic of patients with metastasizing variants was
past or present nonmelanoma skin cancer. The host's exposure to
factors (ie, UV rays) severe enough to cause skin cancers appears to
have a systemic effect not fully studied.
Spratt, Jr JS. Animal Experimentation. JAMA. 1999;281(4):325. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-4-jbk0127