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February 10, 1999

Further Evidence Linking Late-Onset Alzheimer Disease With Chromosome 12

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(6):513-514. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-6-jac80022

To the Editor: We previously reported the results of a genomic screen and initial follow-up in 54 multiplex families with late-onset Alzheimer disease (AD),1 describing linkage to several markers in the centromeric region of chromosome 12. We have since reported linkage to chromosome 12 in an independent sample of Amish families.2 Two research groups3,4 recently reported additional evidence linking late-onset AD to chromosome 12. We now report our additional follow-up studies in relation to these articles.

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