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From The JAMA Web Sites
February 10, 1999

Maintenance Antiretroviral Treatment in HIV Infection

Author Affiliations
 

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(6):514-515. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-6-jac80022

In Reply: Choice of treatment regimen, either doxycycline, 100 mg twice daily for 7 days, or a 1-g dose of azithromycin, was based on local clinic policy, which reflects standard treatment in most clinic settings serving adolescents at risk. We agree that analyzing our data on repeat chlamydia infections by treatment modality or compliance or both may have provided interesting information on efficacy. Although data on treatment regimen were not collected in our study, 2 recent reports compared the efficacy of doxycycline vs azithromycin and found them to be comparable, with treatment failures of less than 5% at 2 to 4 weeks after therapy.1,2 Therefore, we do not believe differentiation of results by treatment regimen or reported patient compliance would have altered our findings.

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