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March NaN, 1999

Control of Outbreaks Due to Organism Producing Extended-Spectrum β-Lactamases

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(12):1080-1081. doi:10.1001/jama.281.12.1080

To the Editor: The optimal approach to controlling an outbreak of organisms producing extended-spectrum β-lactamases (ESBLs) remains unclear. Dr Rahal and colleagues1 noted that restriction of all cephalosporins produced a 44% reduction in ceftazidime-resistant Klebsiella but resulted in a 69% increase in imipenem-resistant Pseudomonas aeruginosa. This report provides several important insights into the difficulty of addressing such outbreaks.

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