Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
Copyright 1999 American Medical Association.
All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999
To the Editor: The optimal approach to
controlling an outbreak of organisms producing extended-spectrum
β-lactamases (ESBLs) remains unclear. Dr Rahal and
colleagues1 noted that restriction of all cephalosporins
produced a 44% reduction in ceftazidime-resistant Klebsiella
but resulted in a 69% increase in imipenem-resistant Pseudomonas
aeruginosa. This report provides several important insights into
the difficulty of addressing such outbreaks.
Lautenbach E, Fishman NO. Control of Outbreaks Due to Organism Producing Extended-Spectrum β-Lactamases. JAMA. 1999;281(12):1080-1081. doi:10.1001/jama.281.12.1080