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March NaN, 1999

Effect of Immediate-Release Glipizide on Hypoglycemic Vulnerability in Fasted, Elderly Patients With Type 2 Diabetes

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(12):1084-1085. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-12-jbk0324

To the Editor: We published a study demonstrating that the hypoglycemic effect of maximal doses of once-daily second-generation sulfonylureas is minimal when administered to elderly subjects with type 2 diabetes during a prolonged fast.1 However, the issue of whether immediate-release sulfonylureas have increased hypoglycemic potential during such a fast remains controversial. Because comparative studies have shown that fasting and postprandial serum insulin concentrations are increased following immediate-release glipizide administration compared with glipizide gastrointestinal therapeutic system (GITS) administration, we investigated whether the risk of hypoglycemia is increased in elderly patients with type 2 diabetes taking immediate-release glipizide compared with glipizide GITS during a prolonged fast.2

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