[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
May 26, 1999

Low-Dose Hydrocortisone for Chronic Fatigue Syndrome

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(20):1887-1889. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526

To the Editor: Dr McKenzie and colleagues1 continued their thorough studies of hypothalamic-pituitary-adrenal axis dysregulation in patients with CFS and found that treatment with hydrocortisone mildly increased their global wellness scale. However, several comments are in order. First, glucocorticoids often induce a feeling of euphoria.2 Because a control population was not studied, the effect may not be specific to patients with CFS since healthy volunteers may also feel "better" when treated with hydrocortisone.

First Page Preview View Large
First page PDF preview
First page PDF preview