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May 26, 1999

Low-Dose Hydrocortisone for Chronic Fatigue Syndrome—Reply

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;281(20):1887-1889. doi:10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526

In Reply: Our study of patients with CFS was designed to evaluate efficacy and safety of hydrocortisone.1 We reported that divided doses totaling 25 to 35 mg/d for 12 weeks provided significant but modest symptomatic relief and also significant adrenal suppression. Our conclusion, then and now, is that the risks associated with low-dose hydrocortisone treatment outweigh its potential advantages for patients with CFS.

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