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July 7, 1999

Inappropriate Secretion of Natriuretic Peptides in a Patient With a Cerebral Tumor

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(1):27-28. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-1-jbk0707

To the Editor: Increased plasma concentrations of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) may occur in myocardial infarction, renal insufficiency, and hypertension.1 The increased secretion of atrial natriuretic peptides from the heart is probably a physiologic reaction to volume overload but also may be due to other mechanisms. We describe a 10-month-old girl with a cerebral tumor and excessive diuresis and natriuresis, thus fulfilling the diagnosis of a cerebral salt-wasting syndrome, as described by Cort2 in the 1950s.

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