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August 11, 1999

Diuretics for Hypertension

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(6):523-525. doi:10.1001/jama.282.6.523

To the Editor: We take exception to Dr Moser's1 labeling of our study2 as widely disseminated misinformation. We showed that in patients who were treated with calcium antagonists, the decrease in ventricular arrhythmias paralleled a decrease in left ventricular (LV) mass. In contrast, patients who were treated with a diuretic experienced no reduction of LV mass or associated ventricular arrhythmias despite a similar decrease in arterial pressure. The article was peer reviewed, revised, and published. Clearly, 10 years later, a variety of potential criticisms could be raised, not the least of which is that the study duration probably was too short. However, this does not make the article "misinformation."

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