Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
Copyright 1999 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.1999
In Reply: Dr Messerli and colleagues are correct
in pointing out that their study was short-term. In 1991, we reviewed data
on the differing opinions regarding the effects of diuretics on LVH and concluded
that LVH regression occurred if blood pressure was lowered.1
The recent meta-analysis, which noted that ACE inhibitors were the most effective
agents in causing regression, included several studies that were short-term
and enrolled limited numbers of subjects. The conclusion may be correct, but
one cannot dismiss data from the Treatment of Mild Hypertension Study and
the Department of Veterans Affairs Cooperative Study Group on Antihypertensive
Agents study, both of which showed that diuretics were as effective or more
effective than other medications.
Moser M. Diuretics for Hypertension—Reply. JAMA. 1999;282(6):523-525. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-6-jbk0811