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August 11, 1999

Diuretics for Hypertension—Reply

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(6):523-525. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-6-jbk0811

In Reply: Dr Messerli and colleagues are correct in pointing out that their study was short-term. In 1991, we reviewed data on the differing opinions regarding the effects of diuretics on LVH and concluded that LVH regression occurred if blood pressure was lowered.1 The recent meta-analysis, which noted that ACE inhibitors were the most effective agents in causing regression, included several studies that were short-term and enrolled limited numbers of subjects. The conclusion may be correct, but one cannot dismiss data from the Treatment of Mild Hypertension Study and the Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents study, both of which showed that diuretics were as effective or more effective than other medications.

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