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August 25, 1999

Aspirin and Risk of Hemorrhagic Stroke

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(8):731-733. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-8-jbk0825

To the Editor: In their exhaustive review of the literature and their meta-analysis of aspirin and risk of hemorrhagic stroke, Dr He and colleagues1 state that "absolute risk measures the magnitude of aspirin use on risk of hemorrhagic stroke." This is not technically correct. It would be more accurate to state that absolute risk measures the risk of hemorrhagic stroke with aspirin or placebo. Absolute risk increase measures the risk of hemorrhagic bleeding attributable to aspirin.

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