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August 25, 1999

Association of the CCR5Δ32 Mutation With Improved Response to Antiretroviral Therapy

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(8):734. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-8-jbk0825

To the Editor: Individuals infected with human immunodeficiency virus type 1 (HIV-1) who are treated with highly active antiretroviral therapy (HAART), including HIV-1 protease inhibitors, experience dramatic benefits.1 However, virologic failure occurs commonly in clinical trials and in practice.2,3 The CCR5Δ32 mutation is associated with decreased susceptibility to HIV-1 infection (Δ32/Δ32) and slower progression to acquired immunodeficiency syndrome (wild type [wt]/Δ32).4 We wished to determine whether the presence of the CCR5Δ32 allele would affect virologic outcome after HAART is initiated.

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