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September 8, 1999

Higher Standards for Epidemiologic Studies—Replication Prior to Publication?

Author Affiliations

Margaret AWinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(10):937-938. doi:10.1001/jama.282.10.937

To the Editor: In his commentary on epidemiologic studies and meta-analysis in drug development and surveillance, Dr Temple1 suggests that medical journals impose 3 higher standards on epidemiologic studies. Two of these should invoke little concern. Who is not in favor of any scientist doing a better job describing methods and their limitations? However, Temple's third suggestion—that epidemiologic studies with relative risks of 2.0 or less not be published until replicated in a different environment—is alarming.

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