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September 15, 1999

Organic Solvent Exposure During Pregnancy and Congenital Malformations—Reply

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(11):1033. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-11-jac90008

In Reply: In our study, most previous miscarriages occurred among women who were working with organic solvents. The fact that the prevalence of previous miscarriages is not reflected in the incidence of miscarriages in the index pregnancy is not surprising. Women who had a miscarriage in the index pregnancy could have had it early enough that they would not have been counseled by our service. Regardless, our data show that major malformations did not occur more often among women with a previous miscarriage.

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