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October 6, 1999

Dietary Fat and Risk of Breast Cancer

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(13):1223-1224. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-13-jbk1006

To the Editor: Although Dr Holmes and colleagues1 imply that a high-fat diet does not increase the risk of developing breast cancer,2 this interpretation may be misleading. After careful examination of both the summary data and model assumptions, we argue that their analysis suffers from multicollinearity, an artifact that may easily have nullified an effect of a high-fat diet on breast cancer.

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