Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
In Reply: Dr Newmark suggests that we did not
find an association between fat intake and breast cancer risk because vitamin
D may protect against a high-fat diet, and average vitamin D intake in our
population is higher than the US average of 60 IU/d.
We performed separate analyses of fat intake and breast cancer risk
among women with low (≤60 IU/d) and high (>60 IU/d) intake of vitamin D.
For a 5% energy increase in fat intake among low consumers of vitamin D, the
relative risk (RR) of breast cancer was 0.95 (95% confidence interval [CI],
0.86-1.04) vs 0.97 (95% CI, 0.94-1.01) among high consumers. These findings
do not support Newmark's hypothesis.
Holmes MD, Rosner B, Willett WC. Dietary Fat and Risk of Breast Cancer—Reply. JAMA. 1999;282(13):1223-1224. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-13-jbk1006