Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor
To the Editor: Dr Tanner and colleagues1 investigated potential genetic contributions to
the cause of sporadic Parkinson disease (PD) through the ascertainment of
PD in monozygotic (MZ) and dizygotic (DZ) twin pairs and found that concordance
for PD was low and was equivalent in MZ and DZ pairs. They concluded that
heredity is not a major causal component in most cases of PD.
Parker, Jr WD, Swerdlow RH, Parks JK, Davis II JN, Trimmer P, Bennett JP, Wooten GF. Parkinson Disease in Twins. JAMA. 1999;282(14):1328-1329. doi:10.1001/jama.282.14.1328