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October 20, 1999

Electron Beam Computed Tomography to Detect Coronary Artery Disease—Reply

Author Affiliations

Margaret A.WinkerMD, Deputy EditorIndividualAuthorPhil B.FontanarosaMD, Interim CoeditorIndividualAuthor

JAMA. 1999;282(15):1422-1423. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-15-jac90009

In Reply: Dr Oudiz suggests that there is a strong correlation between the amount of calcium deposition in a coronary artery detected by EBCT and the degree of coronary artery stenosis detected by coronary artery angiography. Oudiz cites the study of Agatston et al1 to support this claim, but the r values obtained in that study ranged only from 0.62 to 0.68. Moreover, there was tremendous variability about the regression lines, further demonstrating that the correlation is weak. These findings are not surprising given the difficulty in accurately quantifying the volume and geometry of calcium in coronary artery plaques by EBCT,2,3 and the fact that calcium represents only a portion of the composition of a plaque.3

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