Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor
To the Editor: Dr Meier and colleagues1 present intriguing data that individuals with a
first acute myocardial infarction (AMI) were less likely than matched controls
to have used tetracycline antibiotics or quinolones in the previous 3 years.
The authors raise the possibility that organisms susceptible to these antibiotics
may be involved in the pathogenesis of coronary heart disease. However, several
methodological limitations lead to other possible explanations for the observed
Haider AW, Luna M, Patel S, Gaziano JM. Antibiotic Use and Risk of Myocardial Infarction. JAMA. 1999;282(21):1997-1999. doi:10.1001/jama.282.21.1997