Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor
Copyright 1999 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.1999
To the Editor: The study by Dr Strain and colleagues1 seeking an optimal level of medication dose for
treatment of patients in methadone maintenance programs ignores that individuals
vary in how they metabolize a given amount of medication. Just as there is
no optimal insulin or digoxin dose, there is no optimal dose of methadone
for all persons in a methadone maintenance program.
Levinson D. Moderate- vs High-Dose Methadone for Opioid Dependence. JAMA. 1999;282(22):2121-2123. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-22-jbk1208