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December 8, 1999

Moderate- vs High-Dose Methadone for Opioid Dependence

Author Affiliations

Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor

JAMA. 1999;282(22):2121-2123. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-22-jbk1208

To the Editor: The study by Dr Strain and colleagues1 seeking an optimal level of medication dose for treatment of patients in methadone maintenance programs ignores that individuals vary in how they metabolize a given amount of medication. Just as there is no optimal insulin or digoxin dose, there is no optimal dose of methadone for all persons in a methadone maintenance program.

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