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December 15, 1999

Coffee Consumption and Risk of Gallstone Disease

Author Affiliations

Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor


Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999

JAMA. 1999;282(23):2212-2213. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-23-jbk1215

To the Editor: The article by Dr Leitzmann and colleagues1 on coffee consumption and gallstone disease would be stronger if additional data were provided. First, it would be helpful to know the percentage of coffee drinkers (and amount of coffee consumed) in the original study population (N = 51,529) and in those excluded because of prior history of gallstones or cholecystectomy (number not mentioned). In other words, did coffee drinkers develop gallstone disease prior to the beginning of the study? Second, the authors also should provide the risk ratios for new coffee drinkers (or those who have increased their consumption during the study period) and for ex-coffee drinkers (those who have quit or reduced their coffee consumption during the study period) on an adjusted per-year basis. These data would help to further confirm the hypothesis and determine the time frame in which the effects of coffee are expected to occur.

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