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December 22/29, 1999

Treatment of Hyponatremic Encephalopathy

Author Affiliations

Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor

JAMA. 1999;282(24):2298-2299. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-24-jbk1222

To the Editor: I disagree with several conclusions drawn by Drs Ayus and Arieff in their article on chronic hyponatremic encephalopathy.1

First, there was no patient randomization. This creates uncertainty as to whether the persistence of hyponatremia observed is a marker of those individual patients with poor clinical course (and outcomes) and not causal.

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