Phil B.FontanarosaMD, Interim CoeditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephenLurieMD PhD, Fishbein FellowIndividualAuthor
To the Editor: I disagree with several conclusions
drawn by Drs Ayus and Arieff in their article on chronic hyponatremic encephalopathy.1
First, there was no patient randomization. This creates uncertainty
as to whether the persistence of hyponatremia observed is a marker of those
individual patients with poor clinical course (and outcomes) and not causal.
Smith SA. Treatment of Hyponatremic Encephalopathy. JAMA. 1999;282(24):2298-2299. doi:10-1001/pubs.JAMA-ISSN-0098-7484-282-24-jbk1222