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January 26, 2000

Central Venous Catheters and Bloodstream Infection—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorMargaret A.WinkerMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(4):477-479. doi:10.1001/jama.283.4.475

In Reply: We agree with Dr Schierholz and colleagues that the evidence from clinical trials suggests that CSS-impregnated catheters are effective, specifically in high-risk patients requiring short-term catheterization. As we stated in our article, "Including the study [by Logghe et al1] that used paired blood cultures to define CR-BSI [catheter-related bloodstream infections] with the studies in the main analysis increased the summary OR [odds ratio] for CR-BSI, but the results remained statistically significant (OR, 0.67; 95% CI [confidence interval], 0.47-0.95; P = .02)." Thus, the pooled results are statistically significant when the study by Logghe et al is included. The population specified in our recent cost-effectiveness evaluation of antiseptic-impregnated catheters was high-risk patients requiring short-term catheterization.2

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