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February 2, 2000

Glycosylated Hemoglobin as a Diagnostic Test for Type 2 Diabetes Mellitus—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(5):605-607. doi:10.1001/jama.283.5.601

In Reply: Dr Davidson and colleagues raise several issues regarding my editorial addressing the utility of HbA1C in the diagnosis of diabetes mellitus. Davidson et al suggest that they have a perfect test with their proposed scheme for use of HbA1C (ie, no false-positive or false-negative test results). This would be a wonderful (albeit unlikely) scenario for any diagnostic test, and some questions must be asked: (1) compared with which criterion standard? and (2) using what definition of "normality"—statistical, or more desirable prospective scientific studies relating HbA1C values to the development of diabetes complications?

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