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February 9, 2000

Chronic Fatigue: Syndrome or Disease?—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(6):744-745. doi:10.1001/jama.283.6.741

In Reply: No one wishes to deny the symptoms experienced by those diagnosed as having CFS (or, for that matter, the closely related disorder fibromyalgia). The absence of biological markers does not invalidate their complaints. But legitimizing the symptoms as a disease construct serves no one, especially the patient, and is intellectually and fiscally impoverishing. Thoughtful clinicians have turned away from the concept because it makes improvement and cure less likely.

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