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February 23, 2000

Risk of HIV Transmission Through Breastfeeding—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(8):999-1000. doi:10.1001/jama.283.8.999

In Reply: Dr Castetbon and colleagues argue that we may have overestimated the early breastfeeding risk of HIV acquisition because infants were tested too early to exclude a delivery-related transmission of HIV. By design, all infants were older than 4 weeks at the time of the last negative HIV result. By 4 weeks, HIV is detectable in almost all perinatally infected, nonbreastfed infants.1 Hence, it is very unlikely that study infants were infected during delivery.

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