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February 23, 2000

Ventilator-Induced Lung Injury—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(8):1003-1004. doi:10.1001/jama.283.8.999

In Reply: The primary end points of our study were bronchoalveolar lavage (BAL) and plasma concentrations of a number of inflammatory mediators associated with 2 different ventilatory strategies. For safety reasons, we identified a priori criteria to discontinue patients from the study. Seven patients were thus excluded from the study, and we did not obtain cytokine levels at 24 or 36 hours for them. The reasons for the dropouts were documented in our article. Including the patients who dropped out, mortality at 28 days after admission was 59% and 36% and mean (SD) ventilator-free days were 4 (8) days and 12 (11) days in the control and lung-protective treatment groups, respectively. These values are similar to those reported in our article.

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