Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor
Copyright 2000 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2000
In Reply: Our approach would only isolate true
virion particles rather than free viral RNA. Nevertheless, there are data
that suggest that, even in HIV-1–infected patients not treated with
HAART, many of the virions in the plasma during HIV-1 infection are defective.1 This could also be the case in residual disease
during suppressive HAART. Of note, some defective particles may actually represent
aberrant virions from long-lived chronically infected cells that are altered
by protease inhibitors.
Pomerantz RJ, Zhang H, Dornadula G. Residual HIV-1 RNA After Highly Active Antiretroviral Therapy—Reply. JAMA. 2000;283(9):1138-1139. doi:10.1001/jama.283.9.1137