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March 1, 2000

Residual HIV-1 RNA After Highly Active Antiretroviral Therapy—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(9):1138-1139. doi:10.1001/jama.283.9.1137

In Reply: Our approach would only isolate true virion particles rather than free viral RNA. Nevertheless, there are data that suggest that, even in HIV-1–infected patients not treated with HAART, many of the virions in the plasma during HIV-1 infection are defective.1 This could also be the case in residual disease during suppressive HAART. Of note, some defective particles may actually represent aberrant virions from long-lived chronically infected cells that are altered by protease inhibitors.

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