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March 1, 2000

Safety of Antidepressant Medications During Pregnancy

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(9):1139. doi:10.1001/jama.283.9.1137

To the Editor: The pharmacologic treatment of depression during pregnancy presents a therapeutic dilemma for physicians. Prospective data are sparse and decisions regarding which agents to prescribe are made based on retrospective reviews and anecdotal reports. The review by Dr Wisner and colleagues1 of the pharmacologic treatment of depression during pregnancy is a welcome synthesis based on prospective data regarding pregnancy outcomes for women treated with antidepressants. However, their discussion of pharmacologic agents used in the treatment of depression is limited.

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