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March 1, 2000

Safety of Antidepressant Medications During Pregnancy—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor


Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

JAMA. 2000;283(9):1139. doi:10.1001/jama.283.9.1137

In Reply: We included prospective studies in which outcomes for antidepressant-exposed mothers and infants were compared with outcomes for nonteratogen-exposed mothers and infants. Information from pregnancy registries and other studies without control groups has limited usefulness due to methodological weaknesses, as demonstrated in the lithium registry.1 Our goal was to provide a critical review of select articles and a framework for conceptualization of information in the risk-benefit decision-making process. General reviews of antidepressant use during pregnancy have been published elsewhere.2,3

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